At 8:30am (GMT-4) on 14 August, a 7.2-magnitude earthquake rocked southwestern Haiti just 12km northeast of Saint-Louis-du-Sud, about 125 kilometers west of the capital Port-au-Prince. The Haitian Civil Protection General Directorate reported hundreds of collapsed buildings, including hospitals, schools and churches, and thousands of destroyed homes in the provinces of Nippes and Grand’Anse. Thousands of injuries and deaths have been reported. Significant humanitarian access constraints, a fragile security situation and a fast-approaching tropical storm add an extra layer of complexity to humanitarian response efforts in the context of the COVID-19 pandemic.